Scientists discover the mechanisms and function of a type of mysterious immune cell

New findings may lead to the development of more effective therapies for inflammation, wounds and malignant tumors

LA JOLLA, CA – August 31, 2010 –– In two closely related studies, two teams of Scripps Research Institute scientists have discovered the underlying mechanisms that activate a type of immune cell in the skin and other organs. The findings may lead to the development of new therapies to treat inflammation, wounds, asthma, and malignant tumors.

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Human unconscious is transferred to virtual characters

Virtual characters can behave according to actions carried out unconsciously by humans. Researchers at the University of Barcelona have created a system which measures human physiological parameters, such as respiration or heart rate, and introduces them into computer designed characters in real time.

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IRCM researchers pave the way for a better understanding of HIV infection and AIDS

A scientific breakthrough on how HIV takes control of cell division

Montreal, September 3, 2010 – Dr. Éric A. Cohen, Director of the Human Retrovirology research unit at the Institut de recherches cliniques de Montréal (IRCM), and his team published yesterday, in the online open-access journal PLos Pathogens, the results of their most recent research on the role of the Vpr protein in HIV (human immunodeficiency virus) infection and AIDS (acquired autoimmune deficiency syndrome).

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Head start for migraine sufferers

Psychological migraine treatment gives sufferers a confidence boost in their ability to self-manage their symptoms

For severe migraine sufferers, psychological treatments build on the benefits of drug therapy, according to a new study1 by Elizabeth Seng and Dr. Kenneth Holroyd from Ohio University in the US. Their comparison of the effects of various treatment combinations for severe migraine – drug therapy with or without behavioral management – shows that those patients receiving the behavioral management program alongside drug therapy are significantly more confident in their ability to use behavioral skills to effectively self-manage migraines. And surprisingly, the increase in confidence in self-management abilities is greatest among those who feel that they have very little control over their condition before treatment starts. Seng’s and Holroyd’s findings are published online in Springer’s journal Annals of Behavioral Medicine.

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Team discovers new type of anti-malarial compound

Clinical trials for promising new drug candidate are planned

LA JOLLA, CA – August 30, 2010 –– An international team led by scientists from The Scripps Research Institute, the Swiss Tropical Institute, the Genomics Institute of the Novartis Research Foundation and the Novartis Institute for Tropical Diseases has discovered a promising new drug candidate that represents a new class of drug to treat malaria. Clinical trials for the compound are planned for later this year.

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Hair provides proof of the link between chronic stress and heart attack

Researchers at The University of Western Ontario have provided the first direct evidence using a biological marker, to show chronic stress plays an important role in heart attacks. Stressors such as job, marital and financial problems have been linked to the increased risk for developing cardiovascular disease including heart attack. But there hasn’t been a biological marker to measure chronic stress. Drs. Gideon Koren and Stan Van Uum developed a method to measure cortisol levels in hair providing an accurate assessment of stress levels in the months prior to an acute event such as a heart attack. The research is published on-line in the journal Stress.

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Risk of marijuana’s ‘gateway effect’ overblown, new UNH research shows

DURHAM, N.H. – New research from the University of New Hampshire shows that the “gateway effect” of marijuana – that teenagers who use marijuana are more likely to move on to harder illicit drugs as young adults – is overblown.

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Pivotal study finds link between PTSD and dementia

More study needed to determine why veterans with PTSD are more at risk than others

Results of a study reported in the September issue of the Journal of the American Geriatrics Society suggest that Veterans with post-traumatic stress disorder (PTSD) have a greater risk for dementia than Veterans without PTSD, even those who suffered traumatic injuries during combat.

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Chronic Lyme disease: How often is it diagnosed and treated?

Cincinnati, OH, September 2, 2010—The existence of chronic Lyme disease is an issue of sharp debate within the medical community. Some health care workers who call themselves “Lyme literate” insist that chronic Lyme disease is frequently diagnosed and treated by primary care physicians. Others, however, including the American Academy of Pediatrics and the Infectious Diseases Society of America, state that there is no convincing biological evidence that chronic Lyme disease exists. Many doctors are concerned with the potential dangers associated with the prolonged and intensive use of oral and intravenous antibiotics (the recommended treatment for chronic Lyme disease), such as blood clots and life threatening infections. A study soon to be published in The Journal of Pediatrics attempts to determine how often chronic Lyme disease is actually being diagnosed and treated.

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New TB diagnostic proves effective, expedient, study finds

Early NIH support instrumental to development of new tool

WHAT: A molecular test designed to easily diagnose tuberculosis (TB) and detect a drug-resistant form of the bacterium that causes TB can provide much more specific, sensitive and rapid results than currently available TB diagnostics, according to a new study in the New England Journal of Medicine. In a test involving 1,730 patients with suspected drug-sensitive or multidrug-resistant pulmonary TB, the Xpert MTB/RIF TB test successfully identified 98 percent of all confirmed TB cases and 98 percent of patients with rifampin-resistant bacteria in less than two hours.

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