Scientists find candidate for new TB vaccine

Scientists have discovered a protein secreted by tuberculosis (TB) bacteria that could be a promising new vaccine candidate, they report today in Proceedings of the National Academy of Sciences. The protein could also be used to improve diagnosis of TB.

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2 in 1: Multi-tasking protein provides new approaches for anti-tuberculosis drugs

In a paper published today in PNAS, scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, reveal new insights into the workings of enzymes from a group of bacteria including Mycobacterium tuberculosis, the bacterium that causes tuberculosis. The new findings present possible new opportunities for developing organism-specific drugs, which target the pathogen but leave other microorganisms, which are beneficial to us, untouched.

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New hybrid drug, derived from common spice, may protect, rebuild brain cells after stroke

Study from Cedars-Sinai Medical Center presented at American Heart Association International Stroke Conference

LOS ANGELES (EMBARGOED UNTIL FEB. 9, 2011 AT 9:15 PM EST) – Whether or not you’re fond of Indian, Southeast Asian and Middle Eastern food, stroke researchers at Cedars-Sinai Medical Center think you may become a fan of one of their key spices.

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Cancer drug target is promising lead for new TB treatments

A key enzyme in Mycobacterium tuberculosis that enables the microbe to reproduce rapidly could be a golden target for new drugs against tuberculosis (TB), according to a study published in Microbiology on 17 November.

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New dry powder antibiotic targets tuberculosis, reduces treatment time

Arlington, Va. — New research being presented at the 2010 International Pharmaceutical Federation (FIP) Pharmaceutical Sciences World Congress (PSWC) in association with the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition will feature an inhalable dry powder antibiotic that when used alone or with current treatments may significantly reduce treatment for tuberculosis (TB) and multi-drug resistant TB.

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Virginia Tech professor discovers new TB pathogen

Kathleen Alexander, associate professor of wildlife in Virginia Tech’s College of Natural Resources and Environment, has discovered a novel tuberculosis (TB) species in the Mycobacterium tuberculosis complex, a group of pathogens that have adapted by using mammals as hosts. It has been nearly two decades since a new organism was identified in this group; the majority were discovered in the early and mid 20th century.

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New TB vaccine enters clinical testing

Modernized BCG vaccine designed to attack TB at multiple stages

Rockville, MD, USA and Tallinn, Estonia (September 23, 2010) – At an international gathering of TB vaccine researchers in Tallinn today, the Aeras Global TB Vaccine Foundation announced it will initiate a clinical trial of an investigational live recombinant tuberculosis vaccine to be led by researchers at Saint Louis University in St. Louis, Missouri, USA. The announcement was made at the Second Global Forum on TB Vaccine Development.

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How mycobacteria avoid destruction inside human cells

Newly published in PLoS Pathogens

Tuberculosis, or TB, is a dreaded contagious disease of the lungs and other organs. The causative agent, Mycobacterium tuberculosis (or M. tuberculosis), infects roughly a third of the world’s population and one-in-ten to one-in-twenty of the infected population becomes sick or infectious at some point during their lifetime.

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New genomic marker for tuberculosis may help identify patients who will develop the disease

Study highlights how blood profiling techniques could change patient care

It may soon be possible to identify patients who will develop tuberculosis, as scientists have identified changes in the blood specific to the disease. These findings are from an international study published in the August 19 issue of Nature and conducted by doctors and researchers at Nationwide Children’s Hospital using blood profiling techniques to understand infections.

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Antibiotic may reduce stroke risk and injury in diabetics

AUGUSTA, Ga. - A daily dose of an old antibiotic may help diabetics avoid a stroke or at least minimize its damage, Medical College of Georgia researchers report.

Minocycline, a drug already under study at MCG for stroke treatment, may help diabetics reduce remodeling of blood vessels in the brain that increases their stroke risk and help stop bleeding that often follows a stroke, said Dr. Adviye Ergul, physiologist in the MCG Schools of Medicine and Graduate Studies.

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