UM researcher identifies novel treatment for pain in sickle cell disease

Alternative approach found to alleviate pain using much smaller doses than traditional medication treatment

A University of Minnesota Medical School research team led by Kalpna Gupta, Ph.D., has discovered that cannibinoids offer a novel approach to ease the chronic and acute pain caused by sickle cell disease (SCD).

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New drugs to relieve cancer pain

Pioneering research at the Universities of Leicester and Ferrara tests new drugs that could relieve cancer pain

Researchers at the University of Leicester and the University of Ferrara in Italy have collaborated to develop new drugs which have the potential to relieve cancer pain without causing many of the side effects of current pain-treatments like morphine.

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Topical treatments provide effective local pain relief

Gels, creams and sprays containing painkillers such as ibuprofen, diclofenac, ketoprofen, and piroxicam are safe and effective treatments for local pain, according to Cochrane Researchers. A new systematic review they have conducted shows that topical non-steroidal anti-inflammatory drugs (NSAIDs) are more effective than placebos for treating short-term pain and have few side effects.

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Mutation causes intense pain

A mutation that enhances the function of a specific ion channel has been identified as the cause of a rare inherited pain disorder. The research, published by Cell Press in the June 10 issue of the journal Neuron, proposes a potential treatment for the disorder and may lead to a better understanding of chronic pain in humans.

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CoLucid Pharmaceuticals, Inc. announces study data documenting oral efficacy of lasmiditan (COL-144), a selective 5-HT1F receptor agonist, in the treatment of acute migraine attacks

DURHAM, N.C., June 9 — CoLucid Pharmaceuticals, Inc., (”CoLucid”), an innovative biotechnology company focusing on therapies for central nervous system disorders, today announced that its investigational first-in-class Neurally Acting Anti-Migraine Agent (NAAMA), lasmiditan (also known as COL-144), a selective 5-HT1F receptor agonist, was effective when given orally to treat acute migraine attacks, as documented in a Phase IIb study. Results of this study will allow the selection of doses for pivotal Phase III studies of lasmiditan in the acute treatment of migraine, scheduled to begin in fourth quarter this year.

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Researchers find daily ginger consumption eases muscle pain by 25 percent

Contact: Pat O’Connor
poconnor@uga.edu
706-542-4382
University of Georgia
Athens, Ga. – For centuries, ginger root has been used as a folk remedy for a variety of ailments such as colds and upset stomachs. But now, researchers at the University of Georgia have found that daily ginger consumption also reduces muscle pain caused by exercise.

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McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
A new study by researchers from McGill University and the University of British Columbia shows that mice, like humans, express pain through facial expressions.

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Mayo researchers find candidate gene culprits for chronic pain

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
ROCHESTER, Minn. — Chronic pain severely limits patients’ quality of life and is among the cost drivers in U.S. health care. Patients can suffer pain without an apparent cause and often fail to respond to available treatments. Mayo Clinic researchers and collaborators now report that chronic pain may be caused by the inadvertent reprogramming of more than 2,000 genes in the peripheral nervous system. The research findings appear in the current issue of the journal Genome Research.

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U-M study: Use of alternative therapy for pain treatment increases with age and wealth

Contact: Tara Hasouris
tarahaso@umich.edu
734-764-2220
University of Michigan Health System Read more

Scientists learn to block pain at its source

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio Read more

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