Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity

Cold Spring Harbor, NY – The work of a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs.

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Joslin researchers identify pathways leading to activation of good fat

BOSTON – September 20, 2011 – Researchers at the Joslin Diabetes Center have identified for the first time two molecular pathways that are critical to activating a type of “good” fat found in the body, a discovery that could play an important role in the fight against obesity and diabetes.

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Policies that promote healthy eating could cut heart disease deaths by half

Research by the University of Liverpool has found that intervention policies that promote healthy eating could cut the death rate for cardiovascular disease (CVD) by up to 50%.

Professor Simon Capewell from the Institute of Psychology, Health and Well-being found that intervention policies which reduce unhealthy eating habits can have a significant effect on levels of CVD at both an individual and population level.

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Cardiotrophin 1 shows promising results for treatment of obesity and metabolic syndrome

Scientists from the Center for Applied Medical Research (CIMA) of the University of Navarra (Spain) have discovered that cardiotrophin 1, a protein synthesized by muscle cells and adipose tissue, has a marked effect on fat and glucose metabolism. “These new findings add to those we already know on this compound such the anti-ischemic and cytoprotective effects showed in acute liver damage and solid organ transplants gives CT-1 great possibilities to be developed in various serious conditions”, commented Pablo Ortiz, CEO of Digna Biotech.

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Gout prevalence swells in US over last 2 decades

Increase in obesity and hypertension are likely contributors

A new study shows the prevalence of gout in the U.S. has risen over the last twenty years and now affects 8.3 million (4%) Americans. Prevalence of increased uric acid levels (hyperuricemia) also rose, affecting 43.3 million (21%) adults in the U.S. Greater frequency of obesity and hypertension may be associated with the jump in prevalence rates according to the findings now available in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

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Culprits and cures for obesity may reside in our gut

Obesity in the United States is reaching ever more alarming proportions, posing a severe menace to public health and exacerbating a crisis in health care costs both domestically and worldwide.

Now, Rosa Krajmalnik-Brown and fellow researchers at the Biodesign Institute at Arizona State University, in collaboration with Dr. John DiBaise and colleagues at the Mayo Clinic, Scottsdale, are looking into what may be a leading driver in body weight regulation—the diverse zoo of microorganisms inhabiting the human gut.

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Eating a high-fat diet may rapidly injure brain cells that control body weight

Obesity among people who eat a high-fat diet may involve injury to neurons, or nerve cells, in a key part of the brain that controls body weight, according to the authors of a new animal study. The results will be presented Tuesday at The Endocrine Society’s 93rd Annual Meeting in Boston.

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Cut down on ‘carbs’ to reduce body fat, study authors say

A modest reduction in consumption of carbohydrate foods may promote loss of deep belly fat, even with little or no change in weight, a new study finds. Presentation of the study results will be Sunday at The Endocrine Society’s 93rd Annual Meeting in Boston.

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‘Master switch’ gene for obesity and diabetes discovered

Researchers have found that a gene linked to type 2 diabetes and cholesterol levels is in fact a ‘master regulator’ gene, which controls the behavior of other genes found within fat in the body

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New approaches, technological advances offer promise for obesity treatment

Health outcomes explored at DDW 2011

CHICAGO, IL (May 7, 2011) – Research being presented at Digestive Disease Week® (DDW) shows that while there are significantly increased benefits for qualifying patients undergoing bariatric surgery, the potential side effects and outcomes need to be considered when determining whether the surgery is appropriate for patients. DDW is the largest international gathering of physicians and researchers in the field of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

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