Vitamin D may treat and prevent allergic reaction to mold in cystic fibrosis patients

PITTSBURGH, Aug. 25 – Vitamin D may be an effective therapy to treat and even prevent allergy to a common mold that can cause severe complications for patients with cystic fibrosis and asthma, according to researchers from Children’s Hospital of Pittsburgh of UPMC, the University of Pittsburgh School of Medicine and Louisiana State University School of Medicine.

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Older patients offer insight into the future of cystic fibrosis

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Medical and Research Center Read more

MP-376 safe and effective for treatment of P. aeruginosa in cystic fibrosis patients

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
ATS 2010, NEW ORLEANS— A new possible treatment to treat P. aeruginosa in cystic fibrosis (CF) patients appears to be promising, according to research to be presented at the ATS 2010 International Conference in New Orleans.

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Pitt researchers discover big role for microRNA in lethal lung fibrosis

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
PITTSBURGH, April 29 – A small piece of RNA appears to play a big role in the development of idiopathic pulmonary fibrosis (IPF), according to lung disease researchers at the University of Pittsburgh School of Medicine. Their study, which is the first to examine microRNAs in the disease, is available online in the American Journal of Respiratory and Critical Care Medicine.

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Drug may treat cystic fibrosis, other diseases caused by ‘nonsense mutations,’ UAB researcher says

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham Read more

Cystic fibrosis and Crohn’s disease treated successfully with infliximab

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Cystic fibrosis (CF) is the most common life-threatening autosomal recessive disease in Caucasian children; it has an incidence of 1 case in every 2500 children born alive. CF involves an anomalous function of the exocrine glands, caused by a mutation of a gene (cystic fibrosis transmembrane conductance regulator, CFTR) located on chromosome 7, which codes for a protein involved in ion transport through the cell membrane. Pulmonary complications are the most common causes of mortal¬ity, but the presenting symptoms are very often linked to gastrointestinal and pancreatic biliary diseases. These are mainly caused by the unusual viscosity of the secretions in hollow organs and in the ducts of solid organs. Crohn’s dis¬ease (CD) is a chronic inflammatory bowel disease which may be localized throughout the gastrointestinal tract. The association between CD and CF is known; there are reports of a prevalence of CD in patients suffering from CF 17 times higher than in controls.

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Defective signaling pathway sheds light on cystic fibrosis

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
In a study that could lead to new therapeutic targets for patients with the cystic fibrosis, a research team from the University of California, San Diego School of Medicine has identified a defective signaling pathway that contributes to disease severity. In the study, published in the journal Nature Medicine, the researchers report that defective signaling for a protein called the peroxisome proliferator-activated receptor-γ (PPAR-γ) accounts for a portion of disease symptoms in cystic fibrosis, and that correction of the defective pathway reduces symptoms of the disease in mice.

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Research project yields better understanding of the defective protein that causes cystic fibrosis

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology Read more

Scripps research team restores some function to cells from cystic fibrosis patients

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute Read more

Sodium channel blocker shows promise as a potential treatment for cystic fibrosis

Cystic fibrosis patients may benefit from a new therapy that increases airway hydration, preventing the buildup of mucous, which is a key factor in the disease, according to researchers at Parion Sciences in Durham, N.C.

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