La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans

Researchers at the La Jolla Institute for Allergy & Immunology have proven – for the first time in human tissues — the specific immune system T cells which trigger the destruction of type 1 diabetes in the pancreas. The finding is an important advance that verifies in humans several important disease characteristics shown in mouse studies and provides a key focal point for interrupting the disease process.

Read more

Which diabetes drug is best for diabetics with kidney disease?

Sitagliptin is safer and as effective as glipizide in patients with Type 2 diabetes and chronic kidney disease

Highlights

• Sitagliptin is as effective as glipizide at lowering blood sugar levels in patients with type 2 diabetes and chronic kidney disease.
• Sitagliptin is less likely than glipizide to cause dangerously low blood sugar levels.
• Patients on sitagliptin tend to lose weight, while those on glipizide gain weight.

Read more

Researchers find molecule that prevents Type 1 diabetes in mice

Researchers at the University of Colorado School of Medicine have found a specific molecule that can prevent the development of type 1 diabetes in mice and has a similar effect on human cells from diabetic patients.

Read more

Researchers make older beta cells act young again

As a person ages, the ability of their beta cells to divide and make new beta cells declines. By the time children reach the age of 10 to 12 years, the ability of their insulin-producing cells to replicate greatly diminishes. If these cells, called beta cells, are destroyed—as they are in type 1 diabetes— treatment with the hormone insulin becomes essential to regulate blood glucose levels and get energy from food. Now, longtime JDRF-funded researchers at Stanford University have identified a pathway responsible for this age-related decline, and have shown that they can tweak it to get older beta cells to act young again—and start dividing.

Read more

Natural compound helps reverse diabetes in mice

Researchers at Washington University School of Medicine in St. Louis have restored normal blood sugar metabolism in diabetic mice using a compound the body makes naturally. The finding suggests that it may one day be possible for people to take the compound much like a daily vitamin as a way to treat or even prevent type 2 diabetes.

Read more

Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity

Cold Spring Harbor, NY – The work of a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs.

Read more

Joslin researchers identify pathways leading to activation of good fat

BOSTON – September 20, 2011 – Researchers at the Joslin Diabetes Center have identified for the first time two molecular pathways that are critical to activating a type of “good” fat found in the body, a discovery that could play an important role in the fight against obesity and diabetes.

Read more

Yale researchers use uterine stem cells to treat diabetes

Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells.

Read more

UC Davis researchers find disease-causing fat cells in those with metabolic syndrome

Finding supports new high-risk obesity category for diabetes, cardiovascular disease

(SACRAMENTO, Calif.) — UC Davis Health System researchers have discovered biological indicators that help explain why some obese people develop chronic diseases such as diabetes and heart disease, and others do not.

Read more

Gene therapy stimulates protein that blocks immune attack and prevents Type 1 diabetes in mice

Increasing a specific protein in areas of the pancreas that produce insulin blocks the immune attack that causes type 1 diabetes, researchers reported in the August issue of the Journal of Clinical Investigation, published early online.

Read more

« Previous Page — Next Page »