Potential new medicines show promise for treating colon cancer, asthma

ANAHEIM, March 28, 2011 — In what they described as the opening of a new era in the development of potentially life-saving new drugs, scientists today reported discovery of a way to tone down an overactive gene involved in colon cancer and block a key protein involved in asthma attacks. Those targets long had ranked among hundreds of thousands that many scientists considered to be “undruggable,” meaning that efforts to reach them with conventional medicines were doomed to fail.

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Asthma drug could help control or treat Alzheimer’s disease

A drug used to treat asthma has been shown to help reduce the formation of amyloid beta, a peptide in the brain that is implicated in the development of Alzheimer’s disease, according to researchers at Temple University’s School of Medicine.

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Adding new anti-asthma drug to therapy may limit seasonal attacks in children

DALLAS – March 16, 2011 – A new anti-asthma medication dramatically reduced increases in seasonal asthma attacks in children and young adults with allergic asthma, according to a multi-institutional study involving a UT Southwestern Medical Center physician.

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Asthma tied to bacterial communities in the airway

Asthma may have a surprising relationship with the composition of the species of bacteria that inhabit bronchial airways, a finding that could suggest new treatment or even potential cures for the common inflammatory disease, according to a new UCSF-led study.

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Discovery could lead to new therapies for asthma, COPD

Researchers have proved that a single “master switch” enzyme, known as aldose reductase, is key in producing excess mucous that clogs the airways of people with asthma and chronic obstructive pulmonary disease (COPD). The enzyme’s action can be blocked by drugs whose safety has been shown in clinical trials for other diseases – a discovery that could improve therapies for the 510 million people worldwide suffering from asthma and COPD.

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New asthma research breaks the mold

Study finds cause of allergic reaction could be growing in your lungs

Scientists investigating the allergic reactions that asthmatics suffer towards a common mould have discovered that many people with asthma actually had the mould growing in their own lungs.

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Bacteria to blame in asthma attacks in children

“We found a significant relationship between bacterial infections and acute asthma attacks - above and beyond the expected relationship between viral infections and attacks,” says Hans Bisgaard, a professor of paediatrics at the DPAC.

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Largest genetic study of asthma points towards better treatments

An international study looking at DNA from over 26,000 people has identified several genetic variants that substantially increase susceptibility to asthma in the population. The findings, published in the New England Journal of Medicine, will help scientists to focus their efforts to develop better therapies for the illness.

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Research and insights on severe asthma in children

Discussed in Pediatric Allergy, Immunology, and Pulmonology journal

New Rochelle, NY, September 9, 2010—A subset of children with asthma suffers from severe, treatment-resistant disease associated with more illness and greater allergic hypersensitivity, according to the results of the National Heart, Blood, and Lung Institute’s Severe Asthma Research Program (SARP), presented in a recently published article in Pediatric Allergy, Immunology, and Pulmonology, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The article is available free online at www.liebertpub.com/pai

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Study points to key genetic driver of severe allergic asthma

CINCINNATI – Scientists have identified a genetic basis for determining the severity of allergic asthma in experimental models of the disease.

The study may help in the search for future therapeutic strategies to fight a growing medical problem that currently lacks effective treatments, researchers from Cincinnati Children’s Hospital Medical Center report in the Aug. 29 Nature Immunology.

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